Endocrine Abstracts

Introdution: Central diabetes insipidus(CDI) is a rare disease, with multiple aetiologies such as cranioencephalic traumatism and multiple sclerosis (ME). However, the association with ME is not commonly described. The clinical suspicion must be made in the presence of polyuria and polydipsia.Case report: Woman, 67 years-old, revealing history of ME relapsing-remitting subtype with 8 years of evolution, hypertension and dyslipidemia, medicated with inter...

Introduction: People with intracranial organic lesions, including pituitary tumours, may manifest initially as a psychiatric disorder, such as depression, emotional disturbance, anxiety, apathy, neurobehavioral disturbance, cognitive dysfunction and personality disturbance.Case Report: A male patient 45 years old was sent to the Department of Endocrinology of São João Hospital due to a pituitary macroadenoma. The patient referred asthenia, musc...

Introduction: Salivary testosterone (Sal-T) reflects the plasma free testosterone fraction that can flow passively through the salivary glands and appears to be a strong correlation with the Calculated free testosterone (CFT) in both eugonadal and hypogonadal men. Since the collection of saliva is simple, noninvasive and inexpensive, the Sal-T is a promising tool for the screening of hypogonadism. Despite the initial interest that Sal-T has aroused, new clinical studies are ne...

Background: Cabergoline, a dopamine receptor-2 agonist, used to treat prolactinomas was associated with increased risk of cardiac valve disease.Objective: To evaluate prevalence of cardiac valve regurgitation in patients with prolactinomas treated with cabergoline.Design: Open, case–control, prospective.Patients: Fifty patients (44 women, 6 men) and 50 sex- and age-matched control subjects.<p class="...

Background and aims: Thyroid nodular disease (TND) is a common condition in the general population. Malignant nodules occur in 5% of patients with thyroid nodules. Fine-needle aspiration biopsy (FNAB) is considered to be the most reliable method of differentiating benign and malignant thyroid nodules. The purpose of this study was to assess the accuracy of FNABs performed in our Hospital.Methods: We retrospectively reviewed the medical records of patient...

Thyroid hormone (TH) plays a major role in nervous system development. Its deficiency causes severe brain malfunction, which in the human results in cretinism. With the recent availability of new imaging techniques, as small animal PET, it is now possible to study cerebral metabolism in vivo. The aim of this work was to study the in vivo effect of TH on the brain of hypothyroid rats in terms of metabolic function, using PET scanning. For the experiment we used th...

Introduction: Several studies have demonstrated a high incidence of vertebral fractures (VF) in acromegaly, not always correlated with bone mineral density (BMD) value adquired by dual X-ray absorptiometry (DEXA). At trabecular level, GH may alter bone microarchitecture (BM) that predisposes to bone fragility. Trabecular Bone Score (TBS), a textural parameter applied to DEXA to evaluate BM, could be useful to predict VF risk in these patients.Materials a...

IntroductionLeydig cell tumors are rare entities, representing less 0.1% of all ovarian tumors. Generally these tumors are benign and unilateral. Most originate from the hilus cells and, less frequently, from the ovarian cortical stroma. Leydig cell tumors are functioning tumors, frequently associated with virilization symptoms in post-menopausal women.Case reportWe report the case of a 77 year-old female pat...

IntroductionA rarely reported histologic subtype of the papillary thyroid cancer is the Warthin-like variant (WLPTC). This carcinoma resembles the Warthin tumour of the salivary gland by virtue of a papillary pattern of eosinophilic tumour cells associated with a rich lymphoplasmacytic infiltrate in the cores of the papillae. Due to the its rarity, the pathological characteristics and clinical behavior of WLPTC are not well doc...

Introduction: Prevalence of vitamin D deficiency is relatively high worldwide, it is associated with poor skeletal health and has recently been related to other extra-skeletal diseases, probably due to its immunomodulatory effects. Detection and treatment of asymptomatic hypovitaminosis D in healthy adult population is especially relevant to attempt to optimize the overall functioning of the human body.Objectives: To assess the percentage of adult health...